Curriculum Vitae - Todd McGee


Education


Graduate Research


Post-doctoral Research

The goal of my post-doctoral research was the biochemical reconstitution of the process by which HMG-CoA reductase is degraded in the endoplasmic reticulum.


Publications


Moriyama ,T., Sather, S.K., McGee, T.P., Simoni, R.D.1998.Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease. J. Biol. Chem. 273: 22037-22043.

McGee, T.P., Cheng, H.H., Kumagai, H., Omura, S., Simoni, R.D. 1996. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis. J. Biol. Chem. 271: 25630-25638

Bankaitis, V.A., McGee, T.P., Skinner, H.B. and Fry, M.R. 1995. Phospholipid Transfer Proteins. In Molecular Biology Intelligence Unit (R.G. Landes Biomedical Publishers Co., Austin)

Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S. and Bankaitis, V.A. 1997. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature 387: 101-105

Kagiwada, S., Kearns, B.G., McGee, T. P., Fang, M., Hosaka, K. and Bankaitis, V. A. 1996. The Yeast BSD2-1 Mutation Influences Both the Cellular Requirement for Phosphatidylinositol Transfer Protein Function and the Activity of the Pathway for Derepression of Phospholipid Biosynthetic Gene Expression. Genetics 143, 685-697

Skinner, H.B., McGee, T.P., McMaster, C., Fry, M.R., Bell, R.M. and Bankaitis, V.A. 1995. The Saccharomyces cerevisiae Phosphatidylinositol Transfer Protein Effects a Ligand-Dependent Inhibition of Choline-Phosphate Cytidylyltransferase Activity. Proc. Natl. Acad. Sci USA. 92: 112-116.

Whitters, E.A., McGee, T.P. and Bankaitis, V.A. 1994. Purification and Characterization of a Late Golgi Compartment from Saccharomyces cerevisiae. J. Biol. Chem. 269: 28106-28117.

McGee, T.P., Skinner, H.B. and Bankaitis, V.A. 1994. Functional Redundancy of CDP-ethanolamine and CDP-choline Pathway Enzymes in Phospholipid Biosynthesis : Ethanolamine-Dependent Effects on Steady-State Composition in Saccharomyces cerevisiae. J. Bacteriol. 176: 6861-6868.

McGee, T.P., SKinner, H.B., Alb, J.G., Whitters, E.A. and Bankaitis, V.A. 1994. Molecular analysis of phosphatidylinositol transfer protein function. NATO ASI Series (J.O. den Kamp, ed., Springer-Verlag Ltd).

McGee, T.P., Fung, M.K.Y. and Bankaitis, V.A. 1994. Genetic Studies on the Roles of Membrane-Forming Phospholipids. In New Comprehensive Biochemistry Series: Protein-Lipid Interactions (A. Watts, ed., Elsevier Ltd.) p. 163-190.

McGee, T.P., Skinner, H.B., Whitters, E.A., Henry, S.A. and Bankaitis, V.A. 1994. A Phospholipid Transfer Protein Controls the Phosphatidylcholine Content of Yeast Golgi. J. Cell Biol. 124: 273-287.

Whitters, E.A., Cleves, A.E., McGee, T.P., Skinner, H.B. and Bankaitis, V.A. 1993. The SAC1p is an Integral Membrane Protein That Influences the Cellular Requirement for Phospholipid Transfer Protein Function and Inositol in Yeast. J. Cell Biol. 122: 79-94.

McGee, T.P., Fung, M.K.Y. and Bankaitis, V.A. 1992. Debate: Phospholipids and the Golgi Complex. Interpreting the Effects of Blocking PC Biosynthesis. Reply. Trends Cell Biol. 2: 71-72.

McGee, T.P., Whitters, E.A. and Bankaitis, V.A. 1992. Debate: Phospholipids and the Golgi Complex. The Bilayer Couple Hypothesis. Reply. Trends Cell Biol. 2: 69-71.

Cleves, A.E., McGee, T.P. and Bankaitis, V.A. 1991. Phospholipid Transfer Proteins: A Biological Debut. Trends Cell Biol. 1: 30-34.

Cleves, A.E., McGee, T.P., Whitters, E.A., Champion, K.M., Aitken, J.R., Goebl, M. and Bankaitis, V.A. 1991. Mutations in the CDP-Choline Pathway for Phospholipid Biosynthesis Bypass the Requirement for an Essential Phospholipid Transfer Protein. Cell 64: 789-800.